Pharmacogenetics clinical considerations

In view of the apparent complexity of pharmacogenetics and its integration into clinical therapeutics, there are some general, practical queries which merit consideration. These are summarized as follows ... 

There are many potential pitfalls that lie in the way of researchers on the route from the discovery of a mutation in human DNA that codes for a pharmacologically important protein to the development of a clinically useful pharmacogenetic test. Very few such tests have been developed as yet, but a considerable number seem likely to be found useful over the next decade in guiding the treatment of patients with cancer, asthma, depression, hypertension, and pain. 

Kidd RS, Straughn AB, Meyer MC, et al Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9 3 allele. Pharmacogenetics 9 71-80,1999 Kinirons MT, Crome P Clinical pharmacokinetic considerations in the elderly an update. Clin Pharmacokinet 33 302-312,1997... 

---