Pharmacogenetics applications

Shi MM et al. Pharmacogenetic Application in Drug Development and Clinical Trials. Drug Metabolism Disposition 2001 29 591-595. 

FUTURE PHARMACOGENETIC APPLICATIONS IN CHILDHOOD AND ADOLESCENT NEUROPSYCHIATRY... 

Liggett, S.B. (2001) Pharmacogenetic applications of the Human Genome Project. Nat Med 7 281-283. 

Kwiatkowski RW, Lyamichev V, de Arruda M, Neri B. Clinical, genetic, and pharmacogenetic applications of the Invader assay. Mol Diagn 1999 4(4) 353-364. 

There is a vast array of techniques that are currently being used to look for mutations for clinical molecular diagnostic use. The following overview of methods describes some of the most common techniques to detect recurrent mutations used in many diagnostic laboratories. As detection of unique mutations is not of relevance to pharmacogenetic applications, this topic will not be discussed in this chapter. 

Liggett SB. Pharmacogenetic applications of the human genome project. Nat Med 2001 7 281-283. 

Sengupta L K, Sengupta S, Sarkar M (2002). Pharmacogenetic applications of the post genomic era. Current Pharmac. Biotechnol. 3 141-150. 

Meisel C, Roots I, Cascorbi I, Brink-mann U, Brockmoller J. How to manage individualized drug therapy application of pharmacogenetic knowledge of drug metabolism and transport. Clin Chem Lab Med 2000 38 869-876. 

Rioux, P, "Clinical Trials in Pharmacogenetics and Pharmacogenomics Methods and Applications," Am. J. Health-System Pharm., 57, 887-898 (2000). 

Spear BB, Heath-Chiozzi M, Huff J. Clinical application of pharmacogenetics. Trends Mol Med 2001 7(5) 201-204. 

Issues, limitations, and questions related to the application of pharmacogenetics and pharmacogenomics... 

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