Pharmacodynamics transduction, time dependent

Mager, D.E. and Jusko, W.J., Pharmacodynamic modeling of time-dependent transduction systems, Clin. Pharmacol. Ther., 70, 210-216, 2001. 

Signal Transduction Model The pharmacological effects of drugs may be mediated by a time-dependent signal transduction process, which involves multiple steps. Sun and Jusko proposed a signal transduction model to account for the delayed effect of pharmacodynamic responses. This model has been used to characterize the parasympathomimetic activity of scopolamine and atropine in rats. ... 

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See also in sourсe #XX -- [ , , , ]

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