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Pharmacodynamics and Conjugation

Minoxidil sulphate is a potent activator of the ATP-modulated potassium channel and thereby relaxes vascular smooth muscle to give a resultant antihypertensive effect. The actual sulphate metabolite is a relatively minor metabolite, the principal [Pg.95]

3 Lee JT, Kroemer HK, Silberstein DJ, Funck-Brentano C, lineberry MD, Wood AJ, Roden DM, Woosley RL, New Engl. J. Med. 1990, 322,1764-1768. [Pg.98]

4 Manoury PM, Binet JL, Rousseau J, Le-ferre-Borg EM, Cavero IG,/. Med. Chem. 1987, 30,1003-1011. [Pg.98]

Vizziano M, Huie K, Heek MV, Compton DS, Davis HR, Biorg. Med. Chem. [Pg.98]

9 Floyd DM, Dimball SD, Drapcho J, Das J, Turk CF, Moquin RV, Lago MW, Duff KJ, Lee VG, White RE, Ridgewell RE, Moreland S, Brittain RJ, Normandin DE, Hedberg SA, Cucinotta GC,/. Med. Chem. 1992, 35, 756-772. [Pg.98]


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