Pharmacodynamic Therapy with Glucocorticoids A

Desired effects. As antiallergics, immunosuppressants, or anti-inflammatory drugs, glucocorticoids display excellent ef cacy against undesired inflammatory reactions, such as allergy, rheumatoid arthritis, etc. 

Measures for attenuating or preventing drug-Induced Cushing syndrome, (a) Use 

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Effect of glucocorticoid administration on adrenocortical cortisol production (A). Release of cortisol depends on stimulation by hypophyseal ACTH, which in turn is controlled by hypothalamic corticotropin-re-leasing hormone (CRH). In both in the hypophysis and hypothalamus there are cortisol receptors through which cortisol can exert a feedback inhibition of ACTH or CRH release. By means of these cortisol sensors, the regulatory centers can monitor whether the actual blood level of the hormone corresponds to the set-point. If the blood level Luellmann, Color Atlas of Pharmacology All rights reserved. Usage subject to terms 

Regimens for prevention of adrenocortical atrophy. Cortisol secretion is high in the early morning and low in the late evening (circadian rhythm). Accordingly, sensitivity to feedback inhibition must be high in the late evening. 

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