Pharmaceutical information systems selection process

To develop a product from inception to market, the product and process have to be optimised and the process scaled up and transferred to commercial production. Definitions and descriptions of the requirements for all these stages of development are discussed in Chapter 8, although the major discussion is on the preformulation/formulation input to product optimisation. The many factors which a formulator should consider in the selection of pharmaceutical excipients and packaging are discussed. Useful sources of information and techniques for selection such as expert systems and experimental design tools are included. 

Distillation is a widely used unit operation in pharmaceutical manufacture to remove components from a system to an acceptable level. The process engineer is able to assist in the selection of the optimum solvent system, providing vapour-liquid equilibrium information and predictions of the efficiency of the separation. A recent example highlighted the effectiveness of CAPE tools in the design and prediction of distillation performance. 

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