Pharmaceutical dosage forms microspheres

Formulation and dosage form aspects that can impact the site of deposition within the nasal cavity are a key consideration for nasal delivery. The site of deposition can impact absorption due to the differences in the permeability and residence time of the anterior and posterior portions of the nose. A variety of dosage forms such as nasal drops, sprays, gels, powders, or microspheres are available for administering pharmaceuticals by the nasal route, and these options need to be carefully evaluated because the type of dosage form can impact where the formulation is deposited in the nasal cavity and, in turn, the systemic absorption. For example, the bioavailability of nasally administered desmopressin was significantly increased in a spray formulation compared with drops, " likely... 

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