Peterson olefination Subject

Peterson olefination involving cyclopropabenzenyl and cyclopropa[Z ]naphthalenyl anion intervention, respectively. Particularly noteworthy is the fact that subjection of disilyl-containing chromium(O) complexes (104, or its anthracene analogue) to r-BuOK provides C(i) anion without the loss of chromium in the case of 104 Peterson olefination has provided the corresponding complexed alkylidene derivative in high yield (equation 25) ", but the compound is unstable and decomposes upon attempted purification. 

The synthesis was completed as shown in Scheme 1.360. Homer-Emmons reaction of the triene phosphonate 1407 with 1406b and workup with 0.5 N HCl furnished the trienone 1408 in 92% yield with 15 1 E/Z selectivity. Peterson olefination of 1408 with (CH3)3SiCH2CN afforded a 1.7 1 E/Z mixture of protected calyculins in 94% yield. The regioisomers were separated and subjected to global... 

Ketone 325 was then subjected to a Peterson olefination protocol, since various Wittig-type olefination conditions... 

---