Peroxynitrite radical reduction potential

In contrast, CO " radicals, with a reduction potential of 1.59V versus NHE, selectively oxidize biomolecules by one-electron abstraction mechanisms [23]. It has been suggested that in vivo, CO " radicals are formed via homolysis of nitro-soperoxycarbonate derived from the combination (feg = 2.9 x 1()4 M"1 s"1) [24] of carbon dioxide and peroxynitrite ... 

The reaction of peroxynitrite (ONOO ) with a series of phenols (8) in aqueous phosphate buffer or acetonitrile solutions has been examined. A good correlation of substituent effects on competitive reactions with the reduction potential of the radicals... 

The practical significance of the reaction depicted in Scheme 7.43 consists of the development of novel antioxidants carrying chalcogen atoms. Divalent organochalcogen compounds react readily with many types of oxidants (peroxide, peroxyl radicals, peroxynitrite, singlet oxygen, and ozone). The tetravalent organylchalcogenides formed are reduced by many mild reductants. Therefore, compounds of this sort have the potential to act as catalytic antioxidants. 

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