Peroxymaleic acid, oxidations

Peroxyacids are the most widely used class of oxidant for aromatic amino to nitro group conversion and include peroxydisulfuric, peroxymonosulfuric, peroxyacetic, peroxytrifluo-roacetic and peroxymaleic acids. The oxidizing potential of the peroxyacid is, as a rule, proportional to the strength of the parent deoxy-acid. Dimethyldioxirane (DMDO) and ozone have also found use for amino to nitro group conversion. [Pg.149]

The standard methods of oxidation of pyridines and other heteroaromatic nitrogen compounds make use of peroxy acids or hydrogen peroxide in carboxylic acid solution. Peracetic acid, peroxymono-phthalic acid and MCPBA can all convert simple pyridines to the N-oxides. For example, the pyridine (45) was oxidized at nitrogen by MCPBA without attack on the vinyl group. Peroxymaleic acid has... [Pg.749]

Chloroperoxybenzoic acid, monoperoxyphthalic acid, peroxymaleic acid, or peroxytrifluoroacetic acid are also used for the preparation of quinoxaline iV-oxides 4 or 5. [Pg.222]

Oxidation of quinoxalin-2-amine with peroxymaleic acid affords quinoxalin-2-amine 1 -oxide. ... [Pg.222]

Peroxymaleic acid/ienux 3-Chloro-2,5-diisobutyl/1-oxide and 1,4-dioxide 843... [Pg.118]

ChIoro-2-isobuty 1-5-isopropyl Peroxymaleic acid/chloroform/20 3-Chloro-2-isobutyl-5-isopropyl/l-oxide and 1,4-dioxide 740a... [Pg.118]

Amino-3-bromo-5,6-dimethyl Peroxymaleic acid/sodium acetate/60-6S° 2-Amino-3-bromo-5,6-dimethyl/ 1-oxide 907... [Pg.118]

Oxidation of 2-isobutyl-3-methoxy-5-(2 -methylprop-l -enyl)pyrazine (95) with peroxymaleic acid gave 5-(r,2 -epoxy-2 -methyl)propyl-2-isobutyl-3-methoxy-pyrazine 1-oxide (27) (113b). [Pg.189]

Further use of this oxidant to produce a number of poly nitro aromatics was reported by Nielsen and co-workers [71] in their remarkable paper. The authors also reviewed work on the other oxidants used to pass from HN to NO Caro acid, peracetic, permaleic, m-chloroperbenzoic and perbenzoic acids. They pointed out that the power of the oxidant is proportional to the acid strength of deoxy peracid. Peracetic and m-chloroperbenzoic acids are suitable for the oxidation of aliphatic primary amines, whereas peracetic, peroxytrifluoroacetic and peroxymaleic acids are best for the oxidation of ring substituted anilines. Potassium persulphate in sulphuric acid was also used successfully [71 ]. [Pg.42]

Pyrazinethiones (123) with alkyl halides in the presence of base produce pyrazinylthio compounds (124), which are easily oxidized with peroxymaleic acid to the sulfoxides (125). Cyanomethyl sulfoxide (125 = CN) is alkylated on the methylene carbon between the sulfoxide and cyano... [Pg.262]

Hydrogen peroxidelmaleic anhydride Oxidations with peroxymaleic acid... [Pg.42]

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