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Peroxisome proliferator-activated therapy

The activation of the retinoid X receptor, which dimerizes with peroxisome proliferator-activated receptors (PPARs), leads to an enhanced clearance of A(f from the brain of a transgenic mouse model of AD, with increased expression of ApoE and its main transporters. Both a PPARy agonist (ciplitazone) and a PPARa agonist (WT 14.643) are able to protect neurons by modulating mitochondrial fusion and fission, leading to a better response of neurons to oxidative stress, suggesting that a PPAR-based therapy could act simultaneously in different cellular components [437]. [Pg.435]

Etgen, G.J., Oldham, B.A., Johnson, W.T. et al. (2002) A tailored therapy for the metabolic syndrome the dual peroxisome proliferator-activate receptor-a/y agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while improving cardiovascular risk factors in predinical models. Diabetes, 51, 1083-1087. [Pg.386]


See other pages where Peroxisome proliferator-activated therapy is mentioned: [Pg.953]    [Pg.130]    [Pg.397]    [Pg.10]    [Pg.953]    [Pg.261]    [Pg.54]    [Pg.323]    [Pg.141]    [Pg.266]    [Pg.307]    [Pg.653]   
See also in sourсe #XX -- [ Pg.99 , Pg.101 , Pg.126 , Pg.132 ]




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