Permeation of molecules across

The endothelium and basement membrane form a barrier that is difficult for the targeted drug Is cross (jee fSg, 5). IVko plasms membranes and the cell body must be passed before the complex reaches the subendrrtbelial space. Permeation of molecules across the rest of the vessel wall is largely influenced by the... 

Fa is the fraction of dose absorbed into enterocytes from the intestinal lumen after oral administration. The two major processes involved are (1) the dissolution of solid particles into gastrointestinal (GI) fluid and (2) the permeation of molecules across intestinal membranes. 

---