Permeability Screening in Different Phases of Discovery

The screening of permeability coefficients for orally available drugs in the LI phase can be made with the intention to  

In the LO phase the optimization of the compounds starts, and eventually ends in the selection of the candidate drug (CD). The strategy with respect to oral drug permeability in this phase of drug discovery is aimed at  

For the different purposes presented here, cell culture models can provide the basis of screening, biopharmaceutical assessments, and evaluations for mechanistic purposes and some considerations for optimal and rational design are discussed below. 

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