Peripterygia marginata

Dihydroperiphylline (VI/55, Scheme VI/12), a spermidine alkaloid isolated from Peripterygia marginata (Baill.) Loes. [42] was synthesized by a /3-lactam-diazacyclooctane method [41] [43]. Thus, treatment of compound VI/52 with l-bromo-4-chlorobutane and transformation of the resulting chloro-derivative with liquid ammonia in a sealed tube gave VI/54. 

Details concerning the structural elucidation of homaline (57) and the related alkaloids hopromine, hoprominol, and hopromalinol, isolated from Homalium pornyense, have been published. The related spermidine alkaloid periphyllene (58) has been recently isolated from the leaves of Peripterygia marginata. Its structure and absolute stereochemistry were determined by spectral and chemical-degradation studies. 

A review of the Celastraceae alkaloids has appeared and a new structure (47) has been proposed for periphylline, the alkaloid produced by Peripterygia marginata. This new assignment also modifies the structures for isoperiphylline, dihydroperiphylline i.e. 2,3-dihydro-), and neoperiphylline (i.e. 4,5-dehydro-). The synthesis of an eight- and a thirteen-membered-ring compound isomeric with (47) assisted in its structural elucidation. ... 

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