Peripheral Prion Replication and Neuroinvasion

The sites of prion agent replication and spread are largely dictated by whether the etiology of prion disease is sporadic, familial, or acquired. For example, in sCJD and fCJD, disease initiates in, and is largely confined to, the nervous system. In 

vCJD and Oral Routes of Animal Prion Transmission 

CNS Pathogenesis of Sporadic, Familial, and Iatrogenic Prion Diseases 

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