Peripheral neuropathy penicillamine

Indomethacin and chloroquine have been implicated in causing mild sensorimotor neuropathy as well as vascular myopathy. Peripheral neuropathy has been reported in patients treated with penicillamine, but less often than the myasthenic syndrome that develop in some patients treated with this drug. Paresthesiae and muscle weakness have been reported in some patients treated with phenylbutazone (Argov and Mastaglia 1979). In all these sydromes, little evidence exists that they are caused by allergic mechanisms. 

Helmke et al. refer to 3 patients with peripheral neuropathy, which developed shortly after starting penicillamine therapy (20 ). No detafls are given. 

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