Peripheral crowding

Figure 10.50 Preorganisation and peripheral crowding approaches to solution stabilisation of rosette motifs.

Figure 3.2 Peripheral crowding as a strategy to prevent linear aggregates.

The most stable aggregate of Whitesides rosettes family shown in Table 3.1 uses a combination of preorganization (sideways connection of the cyanurate subunits) and peripheral crowding of the melamine subunits for the preferential formation of... 

Figure 3.8 Photoswitchable peripheral crowding of a hexagonal rosette [23],...

We have used two strategies in the design of stable self-assembled gregates based on the CA M lattice namely, preorganization [40] and peripheral crowding... 

Figure 2. Schematic representations of preorganization of three melamine by covalent attachment to a center hub (left) and the formation of a rosette structure due to large groups (depicted here as spheres) by peripheral crowding (right). Melamines and cyanuric acid are represented as disks.

Mathias, J. P., Simanek, E. E., and Whitesides, G. M. (1994) Self-Assembly Through Hydrogen Bonding Peripheral Crowding-A New Strategy for the Preparation of Stable Supramolecular Aggregates Based on the Parallel, Connected Rosettes, J. Am. Chem. Soc 116,4326-4340. 

Medforth CJ, Haddad RE, Muzzi CM, Dooley NR, Jaquinod L, Shyr DC, Nurco DJ, Olmstead MM, Smith KM, Ma J-G, Shelnutt JA (2003) Unusual aryl porphyrin rotational barriers in peripherally crowded porphyrins. hiOTg Chem 42 2227-2241... 

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