Peripheral adiposity signals

Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P (1995) Recombinant mouse OB protein evidence for a peripheral signal linking adiposity and central neural networks. Science 269 546-549... 

Fig. 3. Assessment of signaling in peripheral tissue after systemic administration of Axokine . The left hand group of panels show Western Blot analysis for phosphorylated STAT-3 (upper panel) and STAT-3 (lower panel) in muscle (A), liver (B) and adipose (C) tissues from normal mice 30 min after i.p. injection of Axokine (0.1-1.0 mg/kg), IL-6 (1 mg/kg) or Vehicle. The right hand group of panels shows Northern Blot analysis of mRNA for SOCS-3 (upper panel) in muscle (D), liver (E) and adipose (F) tissues from normal mice 30 or 120 min after i.p. injection of Axokine (0.1-1.0 mg/kg), IL-6 (1 mg/kg) or vehicle.

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