Periodic abstinence efficacy

Given the current literature, antidepressant therapy should be initiated in youth with SUD and depression if the depressive symptoms persist during a period of abstinence, if such abstinence is unable to be achieved, or early in treatment if there is a history of recurrent depression. The efficacy of buproprion (Wellbutrin) in youth with SUD and depression is currently being explored (Solhkhah and Wilens, unpublished data). The antidepressants have little abuse potential and are generally very safe, although buproprion (Wellbutrin) should be avoided in youth with eating disorders or seizures. 

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