Perillartine from Perilla frutescens

As mentioned earlier in this chapter, the a-syn-oxime, perillartine (10) is a semisynthetic compound prepared from a natural product, perillaldehyde, isolated from Perilla frutescens (L.) Britton (Labiatae). Although it is used commercially in Japan, its poor solubility and poor sweetness qualities have limited its further development [20,28]. 

Two natural product derived semisynthetic compounds are utilized as a limited basis, namely, perillartine [28] and neohesperidin dihydrochalcone [45]. Perillartine is an a-jy -oxime and synthesized from perillaldehyde, a constituent of the volatile oil of Perilla frutescens (L.) Britton (Labiatae), and used in Japan as a sweetener for tobacco [28]. Neohesperidin dihydrochalcone is a dihydrochalcone glycoside prepared from a flavanone constituent of Citrus aurantium L. (Rutaceae), which is permitted for use in chewing gum and certain beverages in Belgium and elsewhere [45]. 

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See also in sourсe #XX -- [ , , ]

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