Perhaloalkyl group

Bravo and coworkers explored the chemistry of an enantiomerically pure p-toluenesulfinyl trifluoroacetone (indeed other perhaloalkyl groups were also explored) (Eq. 88) [262, 263]. Treatment with diazomethane led to the stereoselective formation of epoxides, potentially useful C-4 building blocks with a high level of functionality [264] there are many published variations on this basic theme. 

Trihalomethyl, perhaloalkyl, and a,a-dihaloalkyl groups are discussed under halogens below. 

In the perhaloalkyl halide addition to C = C bonds, the radical attack is compatible with the presence of functional groups in the structure of the acetylenic substrate (see Table 6). For example, formation of alkcne 2 and amine 3. ... 

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