Perfluorotributylamine

Isocyanates (M—CH3N=C=0) Loss of F3 in perfluorotributylamine C4H9 from TBDMS derivatives... 

The exact mass of an ion (4 to 6 decimal points) reliably defines its elemental and isotopic composition, while the method is called high resolution mass spectrometry. The measurements are conducted manually or automatically (computerized). Manual measurements are based on the parallel acquisition of the peak of interest with the closest peak of an ion with the known composition. Any compound with an intense ion peak with m/z value in the region +10% may serve as a marker. The most widespread markers are perfluorokerosene, perfluorotributylamine, and other polyfluorinated compounds. The use of these compounds is based on their volatility, as well as on the fact that fluorine is a monoisotopic element. In the spectra of these compounds intense ion peaks randomly cover all the range between m/z 19 and M+. ... 

Perfluorotributylamine, as blood substitute, 4 112-113 Perfluorovinyl ethers, preparation of, 18 329-330... 

Fig. 4.37. El mass spectrum of perfluorotributylamine (mass calibrant FC43) to demonstrate unit resolution of a quadmpole analyzer. The expanded views a-c show peaks separated to almost identical degree.

The first heavier than water internal tamponade was introduced in 1987 by Chang with LPFC [1]. The two perfluorocarbons most used are perfluorooctane and perfluorodecaline. Perfluorotributylamine, perfluoropolyether, perfluorooctyl-bromide and perfluorophenanthrene are less used. LPFC are transparent fluids and are not miscible in water and their main characteristic is their high density (1.76-2.03) [2], Their properties are summarised in Table 1. 

Table 1. Physical characteristics of LPFC perfluorocyclohexan (PFE), perfluorotributylamine (PFBA), perfluoro-n-octan (PFO), perfluorodecaline (PFD) bromo perfluoro-n-octan (PFOB), perfluorophenanthren (PFPN)...

S. Chang, N.J. Zimmerman, T. Iwamoto, R. Ortiz, D. Paris, Experimental vitreous replacement with perfluorotributylamine. Am. J. Ophthalmol. 103 (1987) 29-37. 

H. Terauchi, S. Okinami, Z. Kozaki, H. Tanihara, M. Nagata, Y. Sagawa, Experimental study on the effects of a replacement of the vitreous body with perfluorotributylamine on the rabbit eye, Nippon Ganka Gakkai Zasshi 93 (1989) 294-301. 

Table 3.1.6 Tuning criteria (Agilent Technologies systems, perfluorotributylamine) ... 

While aromatic amines are discussed in Section 5.2.14., various data for aliphatic amines are listed in Table 20. It is worthwhile remembering that tertiary perfluorinated amines, such as perfluorotributylamine. are completely stable, inert and nontoxic compounds, while some partially fluorinated tertiary amines tend to be unstable, eliminating hydrogen fluoride even at low temperature and are therefore toxie. Primary and secondary aliphatic fluorinated amines carrying CF,N groups have not, so far, been isolated due to their instability. 

Perfluorocarbons. In 1966, it was demonstrated (27) that a laboratory mouse could survive total immersion in a perfluorochemical (PFC) solution. This material, similar to commercial Teflon, is almost completely inert and is insoluble in water. A water-soluble emulsion was prepared that could be mixed with blood (28), and in 1968 (29) the blood volume in rats was completely replaced with an emulsion of perfluorotributylamine [311-89-7], C12F27N. The animals survived in an atmosphere of 90—100% 02 and went on to long-term recovery. However, the 02 content of the perfluorochemicals has a linear dependence on the partial pressure of oxygen, P, as can be seen in Figure 1. The very high 02 tension required to transport physiologic amounts of 02 (12) and the propensity of the perfluorocarbon to be taken up by the reticuloendothelial cells were considered to be severe limitations to the development of clinically useful perfluorocarbon blood substitutes (30). 

To ensure accurate mass measurement, spectrometers are calibrated with compounds such as perfluorokerosene (CF3(CF2)nCF3) or perfluorotributylamine ((CF3CF2CF2CF2)3N). In high-resolution spectra, the exact masses of fluorocarbon fragments are slightly lower than those of ions containing C, H, O, N, and S. For high-resolution work, standards should be run with the unknown. 

Before beginning ary analysis, an instrument must be checked for its performance. Every factory-built GC/MS instrument is equipped with a tuning substance, such as perfluorotributylamine (PFTBA). The characteristic mass ions of this compound (or any other tuning compound) and the relative area response corresponding... 

Reference Compounds under Electron Impact Conditions in Mass Spectrometry Major Reference Masses in the Spectrum of Heptacosafluorotributylamine (Perfluorotributylamine)... 

MAJOR REFERENCE MASSES IN THE SPECTRUM OF HEPTACOSAFLUOROTRIBUTYLAMINE (PERFLUOROTRIBUTYLAMINE)... 

Although PDMS is swollen by many organic solvents, it is unaffected by water, polar solvents (e.g., ethylene glycol), and perfluorinated compounds [367]. A detailed study of solvent compatibility of PDMS has been reported. It was found that non-swelling solvents include water, nitromethane, DMSO, ethylene glycol, acetonitrile, perfluorotributylamine, perfluorodecalin, and propylene carbonate [251]. The compatibility of PDMS to other organic solvents can be improved by coating the PDMS surface by sodium silicate [261]. 

Mass Spectrometer. The mass spectrometer was a Hewlett-Packard 5988A quadrupole mass spectrometer with a dual EI/CI source and positive and negative ion detection. The system was controlled by a Hewlett-Packard 1000 computer. The mass spectrometer was periodically tuned manually using perfluorotributylamine (PFTBA) on ions m/z 69, m/z 214, and m/z 502 in El and PCI modes, and on ions m/z 245, m/z 414, and m/z 633 in NCI mode. 

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