Perfluoroalkyl cooper

Perfluoroalkyl cooper reagent also can be generated in situ through the reaction of perfluoroalkyl anions (or their synthetic equivalents) with Cu(I) salts. First part of this section contains a brief review of major types of reagents used for copper mediated... 

Leroy, J. Rubinstein, M. Wakselman, C. Cooper-mediated perfluoroalkylation of halogenothiophenes. J. Fluorine Chem. 1985, 27, 291-298. 

Figure 7.20 Mechanism of cooper mediated perfluoroalkylation of heteroaromatic...

Due to the availability of perfluoroalkyl iodides, this method quickly became the method of choice for the regioselective synthesis of perfluoroalkylated heterocycles. Chen and Tamborski used this reaction for the preparation of variety perfluoroalkyl-pyridines," azines," and triazines." For example, pyridines 72-73 and pyrimidine 74 were synthesized by addition of perfluorohexyl iodide to the agitated mixture of the corresponding heteroaryl bromide, cooper bronze powder in DMSO solvent under nitrogen at elevated temperature (Fig. 7.26)." ... 

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