Perfluoro methyldecalin

Chan et al. [19] used ligand fib in association with Ti(0-iPr)4 in the condensation of aromatic aldehydes with EtjAl in the biphasic hexane-perfluoro(methyldecalin) system at 53 °C [Eq. (2)]. Enantioselectivities in the range 76-88% ee and chemical yields of 77-82% were obtained during six consecutive runs when fresh titanium was added. When the reaction was extended to the electron-deficient 4-chlorobenzaldehyde, the yield was the same (59-88% for three runs) and the enantioselectivity a little lower (63-79% ee for three rrms) for the electron-rich 4-methoxybenzaldehyde, only 10% of product was obtained with an enantioselectivity of 38%. 

Perfluoro methyldecalin Perfluoro(n-propylcyclohexane) Perfluoro(l,3-d iethylcyclohexane Perfluoro(lH-fluorene) Perfluorophenanthrene... 

Note PFH perfluoro- -hexane PFMCH perfluoromethylcyclohexane PFDMCH perfluoro-1,3-dimethylcyclohexane PFMD perfluoro-1-methyldecalin PFTDFIF perfluorotetradecahydrophenanthrene. Measured in deoxygenated solution. ° is determined from the absorption spectra. 

---