Perfluoro-2,5-diisopropyl-3,6-dihydropyrazine

Note Several perfluorinations of pyrazine or piperazine derivatives have been reported The methods do not lend themselves to limited fluorination. Perfluoro(2,5-diisopropylpyrazine) (37) underwent further (additive) fluorination to give perfluoro(2,5-diisopropyl-3,6-dihydropyrazine) (38) (CoF3 + CaF2, 156°C, substrate J, dropwise, N2 87% mechanism discussed).15... 

Difluoro-3,6-bisheptafluoroisopropylpyrazine (perfluoro-2,5-diisopropyl-pyrazine) subjected to fluorination over a mixture of cobalt trifluoride with calcium fluoride at 156° gave perfluoro-2,5-diisopropyl-3,6-dihydropyrazine (74) (1025). 

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