Peptidyl proline-4-hydroxylase

Peptidyl proline-3-hydroxylase (E.C. 1.14.11.-- (L)-Prolyl peptide, 2-oxoglutarate oxygen oxidoreductase (3-(/ )-hydroxylating) (242, 243). 

Ascorbic acid has specific and weU-deflned roles in two classes of enzymes the copper-containing hydroxylases (such as dopamine /3-hydroxylase and peptidyl glycine hydroxylase) and the 2-oxoglutarate-linked iron-containing hydroxylases, of which the best studied are the proline and lysine hydroxylases involved in maturation of connective tissue (and other) proteins. 

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