Peptidomimetics oligomeric

The oligomeric peptidomimetics such as peptoids are particularly interesting compounds since they provide access to an enormous molecular diversity by variation of the building blocks. Peptoids represent a class of polymers that are not found in nature. They differ from the peptides in the manner of side-chain attachment and thus can be considered as peptide mimetics in which the side chain has been shifted from the chiral a-carbon atom in a peptide to the achiral... 

A further amide bond modification, which has been introduced some years ago, is the alkylation of the amide nitrogens all along the peptide backbone [21]. This approach permits the construction of oligomeric peptidomimetics comparable to peptomers, in which the N-substituted glycines are replaced by N-substituted a-amino acids (Fig. 7.3). We could define these oligomers Ca-branched peptoids. 

Peptoids [22] form a particular promising class of oligomeric peptidomimetics, which consists of A-substituted-glycine derivatives. Thus, the concepts to translate a particular peptide sequence, in this case CAAX to a corresponding peptoid sequence is a perfectly suitable approach to obtain potential famesyl inhibitors. This approach was adopted by... 

Kinetically controlled peptide synthesis synthesis ot bioactive peptides in organic solvent (dermorphin, enkephalin) amino acid oligomerization [22] di- and tripeptide synthesis with peptidomimetic leaving group [23-27]... 

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