Peptides, modified

He, K., Falick, A.M., Chen, B., Nilsson, F. and Correia, M.A. (1996) Identification of the heme adduct and an active site peptide modified during mechanism-based inactivation of rat liver cytochrome P450 2B1 by secobarbital. Chemical Research in Toxicology, 9 (3), 614-622. 

Low W, Kang J, Di Gruccio M, Kirby D, Perrin M, et al. 2004. MALDI-MS analysis of peptides modified with photolabile arylazido groups. J Am Soc Mass Spectrom 15 1156. 

Fretz MM, et al. OVCAR-3 cells internalize TAT-peptide modified liposomes by endocytosis. Biochim Biophys Acta 2004 1665 48. 

Marty C, Meylan C, Schott H, et al. Enhanced heparan sulfate proteoglycan-mediated uptake of cell-penetrating peptide-modified liposomes. Cell Mol Life Sci 2004 61 (14) 1785-1794. 

Numerous problems in the construction of chnically applicable drug targeting moieties still need to be solved. Of these issues, immunogenicity after repeated administration, counterproductive hver clearance, and production 5delds are the most important. Although the problem of immunogenicity is beheved to have been solved for monoclonal antibody therapy by the development of humanized and fully human antibodies [110], for other carrier systems such as modified plasma proteins and peptide modified polymers, this remains an important issue. 

Table 1 Photoreactive Peptides Modified with 4-Azido-Based Photophores 16-18-2234-283133-91 ...

Table 2 Photoreactive Peptides Modified with 4-Nitroaryl-Based Photophores116 25-27 34 4348 84100-1081...

Table 3 Photoreactive Peptides Modified with Benzenediazonium-Based Photophores 25-27-34115 ...

Table 4 Photoreactive Peptides Modified with 4-[3-(Trifluoromethyl)-3//-diazirin-3-yl]aryl-Based...

Fig. 12 Illustration outlining MIP film fabrication. The C-terminus nonapeptide epitope is attached through a tether to a glass or oxidized silicon surface by the N-terminal amino acid of the peptide. Monomers are photochemically cross-linked while remaining in contact with the peptide modified surface. Following polymerization, the glass substrate is removed. The protein can now bind to the MIP via its C-terminus nonapeptide epitope. Modified from [114]...

Peptide-modified electrodes for detecting metal ions... 

Peptide-modified electrodes as metal ion selective sensors... 

Our work has been motivated towards making the use of peptide-modified electrodes for detecting metal ions as generic as possible. Essentially, this means developing a generic approach to modifying the electrode so that any peptide can be attached in a manner to provide optimal metal binding capability. 

The stability of the peptide-modified electrodes with repeated use is the final issue in the evaluation of their performance. Between measurements, the electrodes were regenerated by poising the peptide-modified electrode at +0.5Y for 30 s in 0.1M HC104. With repeated accumulation-measurement-regeneration cycles (where the copper concentration in each accumulation cycle was 23 nM) the degradation... 

Peptide-modified electrodes for other metals towards multianalyte arrays... 

E. Chow, Peptide-Modified Electrochemical Sensors for the Detection of Heavy Metal Ions, Vol, The University of New South Wales, Sydney, 2006. 

The determination of metal ions using peptide-modified electrodes... 

---