Peptide Velcro design

The Peptide Velcro design by O Shea et aL (1993) was based on their experience with the GCN4-pl and Fos/Jun systems. The core design— which preceded Harbury s work on oligomer-state selection (Harbury et aL,... 

O Shea EK, Lumb KJ, Kim PS. 1993. Peptide Velcro Design of a heterodimeric coiled coil. Curr Biol 3 658-667. 

Oakley and Kim (1998) have described a simple and elegant experiment to switch the aforementioned Peptide Velcro from a parallel heterodimer to an antiparallel structure. The strategy was straightforward and resulted in a powerful design rule for specifying antiparallel structures. The Acid-pl... 

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