Peptide metabolism, survey

Separate safety pharmacology studies were completed for many peptides in the survey. Separate safety pharmacology studies are usually performed for NCEs but not biopharmaceuticals. Since rodents are typically used for stand-alone central nervous system and respiratory studies, the usefulness of these studies for NCEs is based on the assumption that rodents are pharmacologically responsive or have some of the same metabolites as would be expected in humans. The lack of concern for metabolism and the significant reduction or absence of pharmacology in rodents with most biopharmaceuticals eliminates the relevance of these studies. In contrast to the larger... 

Figure 6.1 Survey of metabolic pathways in rice. BLAST searches were conducted in which the peptide sequences of enzymes known to be involved in metabolic pathways were used to query rice predicted protein databases http //portal.tmii.ore/rice/RicePublicAccess.htmh...

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