Peptide dimers as potent NPY antagonists

The vasculature of the perfused isolated rat kidney contracts intensively in response to a bolus injection of NPY or [Leu31,Pro34] NPY but not to NPY13-36, producing an 

2 In vivo mean arterial blood pressure in normotensive rats 

HEL cell Ca2+ experiments were carried out as described in Table 3. 

The inhibitory potency of the dimers in HEL cells correlates well with their potency in antagonizing the pressor effect ofNPY in anesthetized rats, thus HEL cells may constitute a good model to screen for NPY receptor antagonists as potential antihypertensive agents. 

4 Solution structure of GW1229 insight into the mechanism of binding 

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