Peptide dendron

Figure 11.35 Helical conformational equilibria of dendron-modified alanine residue (A ) within a peptide-dendron conjugate. Peptide-dendron sequences are shown in the table form.

Shao H, Lockman JW, Parquette JR. Coupled conformational equilibria in beta-sheet peptide-dendron conjugates. J Am Chem Soc 2007 129 1884-1885. 

Kim and co-workers used peptide dendrons to form gel-phase assembled materials at relatively high concentrations (8 wt/vol %) [54], They employed both dendrons and symmetric dendrimers constituted from repeating amide units with peripheral hydrophobic chains (Fig. 15). They observed a negative dendritic effect on the thermal stability of the gel as determined from the gel-sol transition temperature (Tgei) measurements. 

Figure 15.3. Peptide dendrons prepared by Reymond et al. on solid support.

The peptide dendrons prepared by Reymond and coworkers via solid-phase synthesis and cleavage (see Figure 15.3) were examined in aqueous solution and in a combinatorial... 

Sb Fne 15.34. Decoration of peptide dendrons with fucosylacetate residues. 

Similar peptide dendrons from the 2.2.2.2 series prepared in a library format were screened, while still on the beads, for potential aldolase activity.Probes forming colored enaminones or releasing fluorescent fragments via enolization or retro-aldol reactions were used for the screening. Lysine- and proline-rich sequences were identified with the enaminone-forming and enolization-sensitive probes. 

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