Peptide Backbone Modifications by DCR

36-74% (3 step protocol step 1 then 2 then 3) 85-97% (2 step protocol step 1 then 2 and 3) 

CuAAC with Cul, ascorbic acid and 20% piperidine in DMF. These conditions ensured dissolution and stabilization of the active copper(I)-species and simultaneously removed the Fmoc-group of the resulting triazole to afford oligomeric peptidotriazoles 18 with very high purity. 

Fukase et al. discovered that non-basic histidine residues accelerated the CuAAC by coordinating and stabilizing the Cu(I)-species, similar to ttiethylamine. This non-basic 

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