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Pepducins

Kaneider NC, Agarwal A, Leger AJ, Kuliopulos A. Reversing systemic inflammatory response syndrome with chemokine receptor pepducins. Nat Med 2005 11 661-665. [Pg.82]

Pepducins Cell-penetrating hpidated (palmitic acid) membrane-tethered peptides, which act... [Pg.171]

Pepducins have been proposed in the literature as another rational approach to identify agonists and antagonists against GPCRs [60]. Pepducins are N-termi-nally palmitylated peptides (Figure 21.28). [Pg.642]

All of this data supported a conclusion that we were looking at physicochemical compound property behavior or an unspecific assay interference property rather than specific interactions with a given receptor. It was surprising that all three assay technologies against various GPCRs showed a clear response to the compounds with exception of the antagonist screen. The conclusion was that in our hands the pepducin approach would not provide a clear rational approach to identify true hits. [Pg.645]

See other pages where Pepducins is mentioned: [Pg.1021]    [Pg.1021]    [Pg.1021]    [Pg.1021]    [Pg.1022]    [Pg.1021]    [Pg.1021]    [Pg.1021]    [Pg.1021]    [Pg.1022]    [Pg.171]    [Pg.641]    [Pg.644]    [Pg.1021]    [Pg.1021]    [Pg.1021]    [Pg.1021]    [Pg.1022]    [Pg.1021]    [Pg.1021]    [Pg.1021]    [Pg.1021]    [Pg.1022]    [Pg.171]    [Pg.641]    [Pg.644]   
See also in sourсe #XX -- [ Pg.171 ]

See also in sourсe #XX -- [ Pg.641 , Pg.642 ]



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Pepducins and Other Modified Peptides

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