Pentobarbital characteristics

Figure 3.5 Comparison of the structures and physicochemical characteristics of pentobarbital and thiopental.

The sesquiterpenes caryophyllene oxide (36) and p-selinene (= p-eudesmene) (37) isolated from the hexane extract from leaves of Psidium guajava var. minor Mattos (Myrtaceae) potentiated pentobarbital sleep and increased the latency for PTZ-induced convulsions in mice blockade of extracellular Ca was observed in isolated guinea-pig ileum with the hexane extract and its fractions containing both sesquiterpenes (Meckes et al. 1997). The similarity between the chemical structures of the sesquiterpenes (34), (35), and (37) is noteworthy and could indicate relevant characteristic patterns required for central activity. 

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