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Pentameric acetylcholine-binding protein

Figure 2.1 Diagram of nicotinic acetylcholine receptor (nAChR) structure. A top view of (A) an a7 nAChR and (B) a p2 nAChR shows that homomeric and heteromeric classes of nAChRs are both pentameric in structure. Each subunit is made up of four transmembrane domains with the M2 domain making up the ion pore. (C) A side view of the four transmembrane regions shows the N terminus, C terminus, and large M3-M4 intracellular loop that make up each nAChR subunit. The extracellular loops are available for binding to ligands and the intracellular loop is available for regulation of the nAChR by intracellular signaling proteins. Figure 2.1 Diagram of nicotinic acetylcholine receptor (nAChR) structure. A top view of (A) an a7 nAChR and (B) a p2 nAChR shows that homomeric and heteromeric classes of nAChRs are both pentameric in structure. Each subunit is made up of four transmembrane domains with the M2 domain making up the ion pore. (C) A side view of the four transmembrane regions shows the N terminus, C terminus, and large M3-M4 intracellular loop that make up each nAChR subunit. The extracellular loops are available for binding to ligands and the intracellular loop is available for regulation of the nAChR by intracellular signaling proteins.
The structure of the acetylcholine receptor is shown in Fig. 16.12. The nicotinic acetylcholine receptor is a pentameric protein complex with the subunit structme a2PvS. Each of the two a-subunits possesses a binding site for acetylcholine. Four potential transmembrane hehces can be identified in each of the five subunits and these are known as Ml—M4. [Pg.489]

This can be activated by nicotine and for this reason is called a nicotinic receplor. The receptor-channel complex is pentameric and is constructed from four different protein subunits (aaPyE in the adult) that span the membrane and are arranged to form a central pore (channel) through which cations (mainly Na+) flow. Acetylcholine molecules bind to the two a-subunit.s inducing a confoimational change that opens tlic channel for about I millisecond. [Pg.19]


See other pages where Pentameric acetylcholine-binding protein is mentioned: [Pg.273]    [Pg.273]    [Pg.118]    [Pg.198]    [Pg.198]    [Pg.86]    [Pg.931]    [Pg.64]    [Pg.299]    [Pg.1784]    [Pg.424]    [Pg.871]    [Pg.850]    [Pg.54]    [Pg.641]    [Pg.1053]    [Pg.373]    [Pg.396]   


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Acetylcholine binding

Acetylcholine-binding proteins

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