Calcigeroside from Calcigera pentamera

Three monosulfated pentaoside glycosides isolated from the Far Eastern sea cucumber Pentamera calcigera, calcigerosides B (82), Cl (83) and C2 (84) were not active in vitro against standard mouse and human tumor cell lines (P-388, A-549, HT-29, and Mel-28) while their desulfated derivatives (85, 86 and 87 respectively) showed moderate cytotoxic activity (IC50 = 5 p,g/ml) [72]. 

Calcigeroside E (54), Fig. (23) is a new disulfated pentaglycoside isolated from the sea cucumber Calcigera pentamera [70]. 

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