Penicillanyl determinant

A more systematic use of reagents carrying some of the other structural determinants described below might reveals a different picture. Recent work by Assem and Vickers (1975) and by Edwards et al. (1982) has indicated the possibility that the penicillamine and penicillanyl determinants may be more frequently involved than hitherto realized. The relatively high frequency of positive skin tests to a penicillamine-polylysine conjugate in patients allergic to penicillins (Schneider et al. 1973) points to the same conclusion. 

Investigations of the formation of antigenic and allergenic determinants of benzylpenicil-hn have identified a list of determinants that inclndes the penicUloyl, penidllenate, peni-cUloic acid, peniUoic acid, penamaldate, penicoyl, penicillanyl, and penicillamine stmctnres. 

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