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Penem antibiotic

Extensive carbapenem and penem antibiotic research has been ongoing since thienamycin was discovered in 1978. However, only the imipenem-cilastatin combination has become a commercial product. Launched in 1985 in the United States as a broad-spectmm hospital product under the name Ptimaxin, this product had worldwide sales of some 300 million in 1988. Sales were predicted to rise to 345 million for the year ending 1989 (154). [Pg.15]

Y. Takeuchi, M. Sunagawa, Y. Hamazume, T. Noguchi, Stability of a 1/3-Methylcarba-penem Antibiotic Meropenem (SM-7338) in Aqueous Solution , Chem. Pharm. Bull. [Pg.247]

Minamimura M, Taniyama Y, hioue E, Mitsuhashi S. (1993) In vitro antibacterial activity and betalactamase stability of CP-70,429 a new penem antibiotic. Antimicrob Agents Chemother 37 1547-1551. [Pg.179]

The enol phosphate (12-4) proved to be a versatile intermediate for the preparation of other penem antibiotics. Thus reaction of this derivative with pyrrazolidine (13-1)... [Pg.554]

S. Mitsuhashi and G. Franceschi, Penem Antibiotics , Springer-Verlag, Berlin, 1991. [Pg.229]

Kojima S, Nadai M, Kitaichi K, Wang L, Nabeshima T, Hasegawa T. Possible mechanism by which the carba-penem antibiotic panipenem decreases the concentration of valproic acid in plasma in rats. Antimicrob Agents Chemother 1998 42(12) 3136-40. [Pg.3593]

Penem antibiotics (Preparation of intermediate - carbamoyloxy-acetic acid (or its esters)... [Pg.306]

Scheme 3. Outline of strategies for the synthesis of penem antibiotics... Scheme 3. Outline of strategies for the synthesis of penem antibiotics...
The hydrogenation/dynamic kinetic resolution shown in Scheme 32 for the production of a penem antibiotic intermediate is carried out by Takasago [72] on a scale of 50-120 t/year, and recently, it was reported that an optimized segphos ligand [81] can achieve even higher stereoselectivities. Similar results were claimed by Chemi [82] with a Ru/tmbtp catalyst. [Pg.87]

Scheme 32 Hydrogenation/dynamic kinetic resolution for a penem antibiotics intermediate... Scheme 32 Hydrogenation/dynamic kinetic resolution for a penem antibiotics intermediate...
Figure 1Z16 (a) General formula for penemic antibiotics = CH(NH2)-C -4(OH) (antibiotic = amoxicillin) (= ampidUin) C -3,5(OCH3) (= methidUin) (= penidUin... [Pg.320]

Matthews SJ, Lancaster JW. Doripenem monohydrate, a broad-spedrum carba-penem antibiotic. Clin Ther 2009 31 42-63. [Pg.501]

See other pages where Penem antibiotic is mentioned: [Pg.828]    [Pg.232]    [Pg.4]    [Pg.555]    [Pg.183]    [Pg.198]    [Pg.224]    [Pg.828]    [Pg.372]    [Pg.372]    [Pg.392]    [Pg.372]    [Pg.372]    [Pg.320]    [Pg.318]    [Pg.87]    [Pg.320]    [Pg.605]   
See also in sourсe #XX -- [ Pg.87 ]



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