Pegylated polymers polyethylene glycol

Polyethylene glycol (PEG) consists of repeating units of ethylene glycol forming linear or branched polymers with different molecular masses. Pegylation is the process by which PEG chains are covalently attached to lEN molecules. Pegylation confers a number of properties on lEN-a molecules, such as sustained blood levels that enhance antiviral effectiveness and reduce adverse reactions, as well as a longer half-life and improved patient compliance (Kozlowski et al. 2001). 

Several of these problems can be solved by polyplex modification with polyethylene glycol (PEG). PEGylation has been broadly explored for surface shielding ( stealthing ) of many liposomal and nanoparticulate carriers. In the case of cationic polymers, Plank et al. [62] demonstrated that complement activation can be reduced when the polymers are PEGylated. Such a modification can be... 

The covalent attachment of polyethylene glycol (PEG) polymers to therapeutic drugs (pegylation) is one of the most widely used and well-established engineer-... 

We analyzed the structure of a carbon nanotube functionalized with polyethylene glycol (PEG). A maximum amount of polymer ensure a better protection of the drug, we therefore analyzed the scenario of maximum PEGylation. The main requirement is a small volume of the drug carrier to ensure an effective penetration of the natural biological barriers and an optimal circulation through the human body. 

Protein and peptide pegylation (conjugation to polymers of long-chain macrogol - or polyethylene glycol) improves the biopharmaceutical properties of active substances. The improvement encompasses increased stability, resistance to proteolytic inactivation and extension of the half-lives. By this the dehvery and efficacy of proteins is improved [31]. 

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