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Pegylated polymers functionalizing

Chenal, M., et al. 2011. First peptide/protein PEGylation with functional polymtrs designed by nitroxide-mediated polymerization. Polymer Chemistry 2(7) 1523—1530. [Pg.54]

PEGylation chemistry deals primarily with the chemical reactivity and specificity of the activated functional group on the PEG molecule in relationship with the targeted site(s) on the biomolecules of interest. Additionally, the size (molecular weight) and configuration (linear, branched, etc.) of the polymer as well as of the biomolecule will also affect the PEGylation reaction. [Pg.390]

An interesting attempt at resin functionalization, microwave-assisted PEGylation of Merrifield resin, has been described [26]. Treating commercially available polystyrene Merrifield resin with poly(ethylene glycol) (PEG 200) at 170 °C for only 2 min afforded the corresponding hybrid polymer combining the advantages of... [Pg.730]

We analyzed the structure of a carbon nanotube functionalized with polyethylene glycol (PEG). A maximum amount of polymer ensure a better protection of the drug, we therefore analyzed the scenario of maximum PEGylation. The main requirement is a small volume of the drug carrier to ensure an effective penetration of the natural biological barriers and an optimal circulation through the human body. [Pg.222]

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See also in sourсe #XX -- [ Pg.206 ]



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