PEG-PLys

Flfftn 6. -SriMMMrig smctuKs of (A) ilird-generaiion ionic dendrimer potphyrim, (B) FGG-PAsp and (C) PEG-PLys Uocic copolymm. 

S. Lee et al./Boundary lubrication of oxide surfaces by Poly (L-lysine)-g-poly( ethylene glycol) (PLI g-PEG) in aqueous media... 

Areal adsorbed mass density data were calculated from the thickness and refractive index values derived Irom the mode equations according to Feijter s formula. A refiactive index increment (dn/dc) value of 0.182 cm /g was used for the protein-adsorption calculations, and a value of 0.202 cm /g, as determined in a Raleigh interferometer, was used for the PLI g-PEG adsorption calculations. All OWLS experiments were conducted in a BlOS-1 OWLS instrument (ASl AG, Zurich, Switzerland) using a Kalrez (Dupont, Wilmington, DE) flowthrough cell as described previously. The flow-though cell was used for studying both PLL-g-PEG adsorption and protein adsorption. The flow rate and wall shear rate were 1 mL/h and 0.83 s, respectively. 

Figure 10.1 Structures of polymers and polymeric drug delivery systems sensitive to pH. (a) pH-sensitive PHSMp°P P (Lee et al., 2008). (b) pH-sensitive ply[Asp(Hyd-PEG)]-block-p[Asp(diaminoethane)] (Lai et al., 2010).

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