Peak plasma concentration single extravascular dose

Figure 12.1 A typical plasma concentration (Cp) versus time profile for a drug that follows first-order elimination, one-compartment distribution and is administered as a single dose of drug by an extravascular route. (Cp)mox, peak plasma concentration f ox/ peak time.

Peak plasma concentration following the administration of a single extravascular dose, or the first dose, is obtained as follows ... 

Equation 12.13 permits determination of peak plasma concentration for a drug administered extravascularly provided the intercept value for an identical single dose, peak time, elimination half life and the dosing interval are known. 

For example, in Eq. 11.12 (for intravenous bolus), (Cp)o represents the intercept of the plasma concentration versus time profile following the administration of a single dose of a drug. In Eq. 12.13 (for extravascularly administered dose), we can obtain the intercept value from the plasma concentration versus time plot. In both Eqs 11.12 and 12.13, the denominator term is identical (i.e. 1 - For an intravenous bolus, maximum or peak plasma concentration occurs at time 0 and, for an extravascular route, maximum concentration will occur at peak time (Fig. 12.3). 

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See also in sourсe #XX -- [ , ]

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