PE Biosystems Pioneer MPS option

The Pioneer MPS option, described in Section 3.1, is a 16-column accessory that can be added to the PE Biosystems Pioneer peptide synthesis system. A 

2 Protein Technologies, Inc. SYMPHONY/Multiplex peptide synthesizer 

The reusable glass reaction vessels for the solid supports have an internal volume of 16 ml and enable synthesis scales up to 0.1 mmol. Alternatively, disposable plastic vessels with 24 ml volume can be used. Resin agitation is 

The system is a floor-standing instrument that includes a vented cabinet for storage of solvents and reagents. Six solvent/reagent reservoirs are available typically for DMF or NMP as a main wash solvent, piperidine-DMF (1 4) for deprotection, DCM as a secondary reagent, HBTU solution for activation, acetic anhydride as a capping solution, and a TFA-based cleavage cocktail. 

The SYMPHONY/Multiplex system includes 20 x 100 ml reservoirs for predissolved amino acid solutions. The standard 100 mM amino acid concentration provides a fivefold excess. The software is designed primarily for in situ HOBt ester activation using HBTU, TBTU, PyBOP, or BOP activators. 

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