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PDE5.

PDE5 5A 3 GAF/activation PKA, PKG cGMP Sildenafil, Vardenafil, Tadalafil,... [Pg.964]

Dipyridamole is a PDE5/PDE6 selective inhibitor that is used widely in conjunction with aspirin to reduce clotting and prevent stroke. More recent studies with a fixed combination of these two drugs (Aggrenox) has been shown in the recent European Stroke Prevention Study 2 to be of greatly added benefit over aspirin alone for prevention of recurrent stroke. [Pg.965]

PDE1, PDE5 SPECS (88 K), CART regression trees based on 2-point pharmacophores 7 hits/19 tested [71]... [Pg.96]

Palmer PDE5 Potency, physicochem, ADME LE, crystallography [57]... [Pg.193]

In addition to the relatively specific inhibitors listed in this table, there are a number of compounds, particularly the methylxanthines (e.g. theophylline, isobutylmethylxanthine (IBMX), papaverine, caffeine), that inhibit most major forms of PDE except the newer forms). SCH51866 is not selective and inhibits PDE1, PDE5, PDE9, and PDE10 with IC50 values shown. [Pg.371]

PDE5 cGMP-binding cGMP Dipyridamol, zaprinast, sildenalfil,... [Pg.235]

See other pages where PDE5. is mentioned: [Pg.857]    [Pg.963]    [Pg.963]    [Pg.965]    [Pg.390]    [Pg.97]    [Pg.98]    [Pg.176]    [Pg.177]    [Pg.200]    [Pg.200]    [Pg.201]    [Pg.201]    [Pg.201]    [Pg.201]    [Pg.201]    [Pg.998]    [Pg.277]    [Pg.348]    [Pg.620]    [Pg.426]    [Pg.361]    [Pg.372]    [Pg.372]    [Pg.373]    [Pg.373]    [Pg.374]    [Pg.374]    [Pg.107]    [Pg.235]    [Pg.235]    [Pg.236]    [Pg.240]    [Pg.240]    [Pg.4]    [Pg.7]    [Pg.8]    [Pg.10]    [Pg.622]   
See also in sourсe #XX -- [ Pg.5 ]



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Indole-type PDE5 Inhibitors

PDE5 (phosphodiesterase type

PDE5 inhibitors

Substrate-analogous PDE5 Inhibitors

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