Pd-catalysed Suzuki-Miyaura cross-coupling

The reaction of interest was first reported by Miyaura and co-workers in 1997 [1]. It was found that the addition of phenylboronic acid, a reagent pioneered for Pd-catalysed Suzuki-Miyaura cross-coupling, to simple a,p -unsaturated ketones was catalysed by Rh(I) complexes. 

Given that trace Pd can mediate cross-coupling processes, it is important that in the development of base-metal catalysed cross-couplings the Pd concentration (down to ppb levels) is determined and appropriate controls conducted. Bedford showed that Pd contaminants were catalytically active in a supposedly Fe-catalyzed Suzuki-Miyaura cross-coupling methodology, employing common aryl bromide substrates. ... 

The Suzuki-Miyaura cross-coupling reaction involves the coupling of an aryl-or vinyl-boronic acid with aryl, vinyl or alkyl halides, commonly catalysed by a Pd complex (Equation (9.3)). 

The complex from Pd(OAc)2 and this bulky di-tert-butylchlorophosphine ligand, after condensation with P-imino-azaphosphatrane, catalyses efficiently the cross-coupling of aiylboronic acids with aryl halides in the Suzuki-Miyaura reaction to provide specific unsymmetrical biphenyls in well over 90% yields [Kingston Verkade J Org Chem 72 2816 2007.]... 

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