Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

PBPK physiologically based

Fig. 13. Scientific elements for estimating exposure and source Environmental health framework. PBPK = physiologically based pharmacokinetic. Fig. 13. Scientific elements for estimating exposure and source Environmental health framework. PBPK = physiologically based pharmacokinetic.
Figure 5.12 The principle of tiering in risk assessment simple questions can be answered by simple methods that yield conservative answers, and more complex questions require more sophisticated methods, more data, and more accurate risk predictions. PEC = Predicted Environmental Concentration, PNEC = Predicted No Effect Concentration, HI = Hazard Index, CA = Concentration Addition, RA = Response Addition, TEF = Toxicity Equivalency Factor, RPF = Relative Potency Factor, MOA = Mode of Action, PBPK = Physiologically Based Pharmacokinetic, BRN = Biochemical Reaction Network. Figure 5.12 The principle of tiering in risk assessment simple questions can be answered by simple methods that yield conservative answers, and more complex questions require more sophisticated methods, more data, and more accurate risk predictions. PEC = Predicted Environmental Concentration, PNEC = Predicted No Effect Concentration, HI = Hazard Index, CA = Concentration Addition, RA = Response Addition, TEF = Toxicity Equivalency Factor, RPF = Relative Potency Factor, MOA = Mode of Action, PBPK = Physiologically Based Pharmacokinetic, BRN = Biochemical Reaction Network.
GLP Good laboratory practice PBPK Physiologically based pharmacoki-... [Pg.2974]

Cai, H., Stoner, C., Reddy, A., Freiwald, S., Smith, D., Winters, R., Stankovic, C. and Surendran, N. (2006) Evaluation of an integrated in vitro - in silico PBPK (physiologically-based pharmacokinetic) model to provide estimates of human bioavailability. International Journal of Pharmaceutics, 308, 133-139. [Pg.451]

Abbreviations [I], inhibitor concentration C ax, maximum plasma concentration Cmax,fu, maximum free plasma concentration /max, maximum portal vein concentration /max,fu, maximum free portal vein concentration PBPK, physiologically-based pharmacokinetics. [Pg.118]

LSD lysergic acid diethylamide PBPK physiologically based pharmacokinetic... [Pg.541]

See other pages where PBPK physiologically based is mentioned: [Pg.262]    [Pg.350]    [Pg.25]    [Pg.130]    [Pg.275]    [Pg.191]    [Pg.296]    [Pg.448]    [Pg.167]    [Pg.489]    [Pg.314]    [Pg.349]    [Pg.172]    [Pg.440]    [Pg.368]    [Pg.333]    [Pg.433]    [Pg.453]    [Pg.473]    [Pg.916]    [Pg.855]    [Pg.247]    [Pg.212]    [Pg.139]    [Pg.558]    [Pg.198]   


SEARCH



Drug PBPK (physiologically based

PBPK

PBPKs

Physiologically Based Pharmacokinetic (PBPK) Modeling

Physiologically based

Physiologically based pharmacokinetic PBPK) model

Physiologically-Based Pharmacokinetic (PBPK) Modelling

Physiologically-based pharmacokinetic PBPK)

© 2024 chempedia.info