Patterning techniques magnetic particles

Postmortem measurements in laboratory animals supply information about regional or local deposition patterns in the lungs at better spatial resolution than noninvasive techniques can provide. Most frequently, radioactively labeled particles are applied, but magnetically labeled particles, microspheres, or fluorescent particles have also been used to quantify deposition throughout the lung on a macroscopic or microscopic level (79). Most of the invasive techniques require special lung fixation procedures before retention analysis to avoid translocation or particle loss during the fixation procedure (11,74). Rapid microwave fixation (80-82), intravascular perfusion techniques (74,83), and cryofixation (84) have been applied (see also Chap. 6). 

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