Pathways and Energy Production

Answer Individuals with uncontrolled diabetes oxidize large quantities of fat because they cannot use glucose efficiently. This leads to a decrease in activity of the citric acid cycle (see Problem 17) and an increase in the pool of acetyl-CoA. If acetyl-CoA were not converted to ketone bodies, the CoA pool would become depleted. Because the mitochondrial CoA pool is small, liver mitochondria recycle CoA by condensing two acetyl-CoA molecules to form acetoacetyl-CoA + CoA (see Fig. 17-18). The acetoacetyl-CoA is converted to other ketones, and the CoA is recycled for use in the /8-oxidation pathway and energy production. 

CHAPTER 18 Metabolic Pathways and Energy Production CH2OH... 

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