Pathophysiology of Acute Pancreatitis

Interleukin 1 (IL-1) and tumor necrosis factor a (TNF-a) hold the central posi- 

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The 19th century witnessed the beginning of studies on the pathophysiology of acute pancreatitis. In 1867 Kiine isolated an enzyme catalyzing the cleavage of peptide bonds, which was later termed trypsin (1877), and a few years later Heidenhain found trypsin in pancreatic cells in the form of inactive proenzyme. 

FIGURE 39-2. Pathophysiology of acute pancreatitis initiating and secondary events. PAF, platelet-activating factor TNF-a, tumor necrosis factor-a IL-1/J, interleukin-1 / IL-6, interleukin-6 IL-8, interleukin-8. 

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